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Symbol
Name
ID

Rac1
Rac family small GTPase 1
MGI:97845

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Recurrent otitis media	Eczematoid dermatitis	Recurrent pneumonia
Disease(s) Associated with RAC1
autosomal dominant intellectual developmental disorder 48

Mouse Phenotypes		immune system phenotype	impaired neutrophil chemotaxis	enlarged spleen	decreased neutrophil cell number	decreased leukocyte cell number	abnormal spleen morphology	impaired neutrophil recruitment	abnormal lymph node morphology	enlarged lymph nodes	decreased acute inflammation
Availability	Mouse Genotype	immune system phenotype	impaired neutrophil chemotaxis	enlarged spleen	decreased neutrophil cell number	decreased leukocyte cell number	abnormal spleen morphology	impaired neutrophil recruitment	abnormal lymph node morphology	enlarged lymph nodes	decreased acute inflammation
	Rac1^em1(IMPC)Mbp/Rac1⁺
	Cd19^tm1(cre)Cgn/Cd19⁺ Rac1^tm1Tyb/Rac1^tm1Tyb (conditional)	*
	Rac1^tm1Djk/Rac1^tm1.1Djk Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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